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男爵府

積分: 9496


221#
發表於 10-5-8 16:38 |只看該作者
Hello Apple8,

Not much advanced technique required except having to culture the embryos for 2 more days. However, the technique for freezing any surplus blastocysts may be more demanding than freezing day-2/day-3 embryos. This is also one of the reasons why clinics don't offer D5ET as a routine.

cutecutetown

原帖由 Apple8 於 10-5-7 12:47 發表
Does the lab needs advanced technique and requirement for growing an embryo to a day 5 blastocy? Is this technique mature in HK?


男爵府

積分: 7527


222#
發表於 10-5-10 16:01 |只看該作者
Hi cutecutetown,

我都係有息肉問題, 請問割完之後最快可幾時放胎架??唔該.


男爵府

積分: 9496


223#
發表於 10-5-10 17:30 |只看該作者
Hello GB,

I am not a medical doctor, so my opinion may not have taken all clinical conditions into consideration. My opinion is that if your have your polyp removed with no other complications, your doc may want to see your normal period return first before planning the FET. If you don't have any ovulatory issue, an FET is relatively straight forward. You will get your FET within a few months after the little polyp surgery.

Hope this helps to plan your time. cutecutetown


原帖由 GB 於 10-5-10 16:01 發表
Hi cutecutetown,

我都係有息肉問題, 請問割完之後最快可幾時放胎架??唔該.


男爵府

積分: 7298


224#
發表於 10-5-11 19:21 |只看該作者
Dear cute cute town,

my ivf failed. Dr asked me to try nasal spray next cycle. He said it is a transitional way and may not have many follicle but ask me to try as last time not much reaction even using high dosage of injection. Can you tell me what are the different between nasal spray and tummy injection and adv and disadv? Thx!
原帖由 cutecutetown 於 10-4-22 00:27 發表
Dear MusicTV,

Great, so your doc also keeps the options open for you. The variation in size always happens, some follicles will be bigger while some smaller. By ultrasound and bloodtests, your doc ...

[ 本帖最後由 MusicTV 於 10-5-11 23:19 編輯 ]


男爵府

積分: 9496


225#
發表於 10-5-12 16:37 |只看該作者
Dear MusicTV,

I am sorry about the failed cycle. How many eggs you had and how many embryos were transferred?

In terms of the ovarian stimulation method, was this cycle of IVF similar as your previous IUIs (except for the drug dosage)?

The use of nasal spray is more of a traditional method involving down-regulation of your body. We call it the "long protocol" because it takes longer time compared to other methods. However, this is a widely-used and well-established method and most IVF success in the 80s to 90s were using this method. Many centers worldwide are still using it as the main method for IVF. The science behind (I try to keep it simple) is that the spray tells the body/ovaries to be at rest so that they won't produce the regular hormones required for a menstrual cycle. After about 2 weeks of spray, the doc will judge by ultrasound and bloodtests to see if the ovaries are "quiet"; if no, there will be another week of spray and check again. If the ovaries are quiet, the doc can give you hormones (mainly FSH, in the form of tummy injections) to tell the ovaries to work, i.e. to produce eggs.

I think your last cycle utilized the "antagonist protocol", involving the use of Cetrorelix or Ganerelix (same type of drugs, but produced by 2 different companies). This method came into use in around mid-1990's and has become more & more popular. The general trend is to use this method for women with poorer response. The time requirement is shorter because on the first day of menses, you receive the FSH injections. Again, the FSH tells the ovaries to produce eggs, but since the ovaries are not being quieted down, they are also producing some other hormones, "thinking" that a normal ovulatory cycle is still operating. So, by about day 6 or so, your doc gave you the antagonist in addition to the daily FSH injection, which prevents the body from ovulating as if in a natural cycle. When your eggs were mature, you were given HCG instead to trigger ovulation, which should be the last shot (not on the tummy but inject into your buttock) before the egg retrieval.

The difference, as you may have already figured out, is that the long protocol involving nasal spray will take longer. To regulate your body downward (achieved by the spray) takes time, usually about 2 weeks. The advantage is that with quiet ovaries, egg production will be more sychronized (i.e. most eggs start growing at the same time and should grow at similar pace). Also, almost all ivf doc's are very experienced with this method. The disadv. is that the time of the whole process takes longer, and sometimes some ovaries may be over-suppressed; this in turn may require more drugs to tell the ovaries to get to work.

Notice that in both methods, you will still receive the tummy injections. These injections are FSH which tells the ovaries to work and also keep the eggs growing.

I have probably already overwhelmed you with too much biology. Let me know if you need more clarification, or simpler explanation.

cutecutetown


原帖由 MusicTV 於 10-5-11 19:21 發表
Dear cute cute town,

my ivf failed. Dr asked me to try nasal spray next cycle. He said it is a transitional way and may not have many follicle but ask me to try as last time not much reaction even us ...


大宅

積分: 1953

好媽媽勳章


226#
發表於 10-5-12 17:50 |只看該作者
cutecutetown,

我想問我噴鼻時, 每次都有水流番出來, 會否影響效果? 我是否噴得唔好?! 我係先呼氣, 噴入, 吸一下, 閉氣 10 秒, 但之後仍有水流出來呢!! 我每次都隔一陣就 feel 到個喉嚨苦苦地, 唔知個鼻膜有冇吸收到呢?

Thx.


大宅

積分: 1794


227#
發表於 10-5-12 18:07 |只看該作者
Hi Cutecutetown,

I have just finished the surgery on this Monday and finally I got 16 grade 1 and 4 grade 2+ embryos to be frozen ( I can't do the fresh embryo plant this cycle as I have high hormone of 23,000) . The doctor said my embryos are in good quality and may be frozen after 5 days because they wanted the embryos to develop better before frozen them, but finally they frozen my embryos today, it was 2 days earlier. I wonder why they frozen my eggs in early time and not to give them more time to develop. Thank you in advance.

Susan


男爵府

積分: 7298


228#
發表於 10-5-12 21:16 |只看該作者
Dear cutecutetown

Thanks for your detail explanation. I totally understand what you've told.

What I ask you such a question is that before ivf, I tried ivf but less eggs so shifted to iui. Then I noticed some jm here use nasal spray so I asked the nurse in the hospital about that. However, at that moment, the nurse told me this is not a method for high age. It won't work on me. So I wonder why this time the dr ask me to try. And the dr said it will even less eggs produce in my case. If not work on me why use nasal spray method on me? What do you think?

For your info, my first and second iui only got 3 eggs. Last ivf 6 eggs with 2 embryos so no frozen.

原帖由 cutecutetown 於 10-5-12 16:37 發表
Dear MusicTV,

I am sorry about the failed cycle. How many eggs you had and how many embryos were transferred?

In terms of the ovarian stimulation method, was this cycle of IVF similar as your previ ...

[ 本帖最後由 MusicTV 於 10-5-12 21:19 編輯 ]


男爵府

積分: 9496


229#
發表於 10-5-13 13:50 |只看該作者
Hello BabyLi2010,

You are already doing very well with the nasal spray. The "residual liquid" should not affect outcome. In your next clinic visit, your doc will use ultrasound to see if your ovaries are quiet, i.e. down-regulated by the spray. No matter how good or bad you did the spray, some people may need to continue the spray for another week while some will start getting their daily hormonal injections.

Good luck and hope to hear from you again.
cutecutetown

原帖由 BabyLi2010 於 10-5-12 17:50 發表
cutecutetown,

我想問我噴鼻時, 每次都有水流番出來, 會否影響效果? 我是否噴得唔好?! 我係先呼氣, 噴入, 吸一下, 閉氣 10 秒, 但之後仍有水流出來呢!! 我每次都隔一陣就 feel 到個喉嚨苦苦地, 唔知個鼻膜有冇吸收 ...


大宅

積分: 1953

好媽媽勳章


230#
發表於 10-5-13 14:05 |只看該作者
thank you ar cutecutetown... 我係醫院做, 好似一定要噴鼻噴到抽 egg 呢!!

另外, 我想問下如果放胎後, 醫生要放尿, 係咪唔係咁好呢?! 因為我擔心放尿會有尿道炎呢!


男爵府

積分: 9496


231#
發表於 10-5-13 14:14 |只看該作者
Hello susan19771118,

Great, if I am not mistaken, you have 20 good-looking embryos. Many jm here will be jealous!

It usually depends on the lab policy to decide whether the embryos should be frozen on day3 or day5. Theoretically, there is no difference on which day the embryos are frozen, as long as they are competent embryos. But practically, out of the 20 day-3 embryos, by growing them to day-5, you may have fewer to freeze because some will not continue to grow, due to natural selection.

When you will return for FET, upon thawing of your embryos, the lab will usually let them develop overnight. But with day-5 frozen-thawed embryos, many labs will thaw on the same day and we won't have much time to "see" if the embryos are growing. So, there are both pros and cons to freezing on different days.

Either way, your embryos should now be safely stored until you are ready for an FET. Rest well, and do not hesitate to contact your clinic if you feel bloated (a swell-up tummy).

cutecutetown

原帖由 susan19771118 於 10-5-12 18:07 發表
Hi Cutecutetown,

I have just finished the surgery on this Monday and finally I got 16 grade 1 and 4 grade 2+ embryos to be frozen ( I can't do the fresh embryo plant this cycle as I have high hormone ...


男爵府

積分: 9496


232#
發表於 10-5-13 14:33 |只看該作者
Dear MusicTV,

I think your doc suggested the long protocol (with nasal spray) because he/she is hoping to get you the eggs. Yes, based on your response, you should use the antagonist protocol just like your previous attempts. However, the nasal spray may give a better synchronized group of eggs. Afterall, everybody responds somewhat differently even to the same drug; something that works for others may not work for you or vice versa. So, it may be worthwhile but quite risky to try (i.e. there may be 2 follicles and need to convert to iui again).

I am assuming that you still accept the possibility of accumulating embryos from 2-3 cycles before having a ET procedure, then it is the best to discuss with your doc which method will best suit your need.

No easy decision, perhaps you want to let your body rest a little (say 2 months) before starting this whole pursuit again?

cutecutetown

原帖由 MusicTV 於 10-5-12 21:16 發表
Dear cutecutetown

Thanks for your detail explanation. I totally understand what you've told.

What I ask you such a question is that before ivf, I tried ivf but less eggs so shifted to iui. Then I n ...


男爵府

積分: 9496


233#
發表於 10-5-13 14:43 |只看該作者
Dear BabyLi2010,

Yes, you will need to continue the spray while at the same time getting daily injections. When you can stop nasal spray (i.e. after 抽 egg), you will have another "course" of things to do...

You jump way ahead to embryo transfer, but it's good to be prepared. On that day of ET, before such procedure, the clinic will ask you to drink plenty of water. The purpose is to have a full bladder, which somewhat helps to straighten up the uterine cavity, making an easier ET process. Remember that you are allowed some time (~30min) of bed rest after the ET procedure; so, if you can hold onto your bladder without having to go to the washroom during that bed rest time, then of course you won't need 放尿. It is only for some who have a super-full bladder or who easily needs to urinate.

cutecutetown :)


原帖由 BabyLi2010 於 10-5-13 14:05 發表
thank you ar cutecutetown... 我係醫院做, 好似一定要噴鼻噴到抽 egg 呢!!

另外, 我想問下如果放胎後, 醫生要放尿, 係咪唔係咁好呢?! 因為我擔心放尿會有尿道炎呢! ...


男爵府

積分: 7298


234#
發表於 10-5-13 17:50 |只看該作者
Thanks for your info.

I do ask the accumulating question to my dr however this time he didn't suggest.

and seems this is the last attempt for me and said o matter 3 or 4 follicles, do one more time ivf.

anyway, i got no choose but trust him.

Btw, long time before (half year before)I've booked another dr for the first vist in the end of may, do you think it's worth to have a visit to seek second opinion?

原帖由 cutecutetown 於 10-5-13 14:33 發表
Dear MusicTV,

I think your doc suggested the long protocol (with nasal spray) because he/she is hoping to get you the eggs. Yes, based on your response, you should use the antagonist protocol just l ...


大宅

積分: 1794


235#
發表於 10-5-13 21:17 |只看該作者
Hello Cutecutetown,

You are right, I have 20 frozen embryos in total. I was surprised when I heard this good news, my doctor said it may be because I am still young ( 33-years-old ). My case of infertility is unknown reason. We have tried for 10 years for having a baby but not working.

Thank you for your kind caring of my tummy, actually I didn't have any special uncomfortable feeling even I had high hormone and many eggs. Thank God.

I got another question wanna ask for your help. My doctor had half of my embryos fertilization by icsi ( she picked one sperm to put inside one egg ), and the rest of them by letting the sperms swim and the best one will finally get inside the egg. I knew that the quality of embryos produced by nature swimming of sperm is better than icsi. However, why is my doctor using icsi for half of my embryos? As far as I knew, icsi just suitable for those couples who with men's problem.
By the way, will the lab separate the embryos with icis and the ones with nature swimming? Please help again. Thank you very very much.


All the best,
Susan


原帖由 cutecutetown 於 10-5-13 14:14 發表
Hello susan19771118,

Great, if I am not mistaken, you have 20 good-looking embryos. Many jm here will be jealous!

It usually depends on the lab policy to decide whether the embryos should be frozen ...


男爵府

積分: 9496


236#
發表於 10-5-14 12:23 |只看該作者
Dear MusicTV,

If cost is not your main concern, then I would probably seek another opinion in your coming-up appointment. After that, you can decide if you really want an ivf cycle by nasal spray with your current doc.

cutecutetown

原帖由 MusicTV 於 10-5-13 17:50 發表
Thanks for your info.

I do ask the accumulating question to my dr however this time he didn't suggest.

and seems this is the last attempt for me and said o matter 3 or 4 follicles, do one more time ...


男爵府

積分: 9496


237#
發表於 10-5-14 12:56 |只看該作者
Dear susan19771118,

Historically, ivf was used to treat women with tubal problems. Then, icsi came along in the early 1990's to help couples where the husbands had sperm issues. There are still debates that icsi embryos are not as good as ivf. In my opinion, it may not be the technique itself that causes the difference; it's the sperm involved being the key. Although we in the lab pick and choose during the ICSI procedure, we only base our judgement on the appearance+motility of the sperm but not its genetic components. So, the answer is yes, icsi embryos tend to be worse than ivf when poor sperm is involved. However, my personal experience tells me that if the man produces normal-quality sperm and icsi is done because of other reason(s), then embryo quality is comparable to those of ivf.

Back to your concern on why half ivf/half icsi on your eggs. As you mentioned, you are relatively young but tried to conceive naturally for 10 years without success. You have no ivf before, husband's sperm seems normal; you have no blocked tubes either (that's why classified as "unexplained".) The "half icsi" portion is like an insurance because icsi will almost always give ferilization while ivf may not. My team (both the doc and lab staff) would have suggested similar treatment if you come to us; but perhaps discuss with you first so that you don't guess and worry later :)
I have had cases in the past where the ivf half had complete fertilization failure. Sometimes sperm can be tricky even when they show good count, motility, and morphology. Their fertilization potential cannot be easily diagnosed by a semen analysis.

I am not sure if the lab that took care of your embryos would freeze them separately according to the method of fertilisation. You may call and check, and request particular embryo(s) to be used first when you have your FET. My usual practice is to freeze in groups of 2 embryos and thaw the best ones first to give the patient the best chance, regardless of ivf/icsi.

Hope this helps. cutecutetown

原帖由 susan19771118 於 10-5-13 21:17 發表
Hello Cutecutetown,

You are right, I have 20 frozen embryos in total. I was surprised when I heard this good news, my doctor said it may be because I am still young ( 33-years-old ). My case of infer ...


大宅

積分: 1794


238#
發表於 10-5-14 13:26 |只看該作者
Hello Cutecutetown,

Thanks a lot for your detail explanations to my questions. I do appreciated it. By the way, I found out there is a methold named PGD which can sort out the embryos with genetic problems while I was surfing the website today, this is such a good thing for us who are doing ivf treatment, we can avoid the possibility of having abnormal baby with this technique. I wonder why it hasn't been commonly used as part of IVF procedures? Is it because the high cost? Thanks again.

SUSAN





原帖由 cutecutetown 於 10-5-14 12:56 發表
Dear susan19771118,

Historically, ivf was used to treat women with tubal problems. Then, icsi came along in the early 1990's to help couples where the husbands had sperm issues. There are still deb ...


大宅

積分: 2277


239#
發表於 10-5-14 14:21 |只看該作者
hi cutecute town,

im 43 and 已結扎, but i want to hae a baby with my present husband. Can i do IVF? pls pm me if you can help me.


男爵府

積分: 9496


240#
發表於 10-5-14 15:01 |只看該作者
Dear Susan,

Theoretically, PGD is a very attractive option; but as you would expect, there are always two sides to a coin.

Currently, there are only 2 ivf centres in HK that offer PGD. The technique involves the removal of 1 to 2 cells from each of your embryo, usually done on day 3 of embryo development, about 8-cell stage. While the removed cell(s) are taken to do genetic tests, the embryo will be kept in culture until the diagnosis is ready to decide if it is "good" for ET. Up to this point, you can see a few uncertainties exist: 1. Will the embryo survive the ordeal? 2. What test(s) can be done on the removed cells? 3. Can the result of this single cell be representative of the whole embryo?

These 3 questions remain to be questions, although they are being solved.....slowly.... with better methods and technologies. But assuming one day scientists will solve them all, we must ask ourselves, how do we define "abnormal babies"? There will be no test whatsoever to give us a "perfect" baby, although major physical malformations and/or mental retardation can be avoided. Generally speaking, the more tests you want to have, the more costly the treatment becomes.

I somewhat agree (only somewhat) with the general consensus that it may not be worthwhile to do PGD for simply checking chromosome number. This is because the current technology can only screen for a max of 12 pairs of chromosomes, when there should be 23 pairs in a "normal" human. However, if there is a family history of some genetic diseases, e.g. thalassemia, then PGD is very helpful to avoid the birth of an affected child.

I really hope one day I can recommend PGD to the jm here, but at this time point, let alone the cost, it is only suitable for a very selected group.

cutecutetown

原帖由 susan19771118 於 10-5-14 13:26 發表
Hello Cutecutetown,

Thanks a lot for your detail explanations to my questions. I do appreciated it. By the way, I found out there is a methold named PGD which can sort out the embryos with genetic pr ...

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