I used it with Regain 5% 8 yrs ago. They worked for me. However, hair starts lossing when medications ceased. You can't take it for the rest of your life. Not much now left on my head, but I found it's ok & no pressure. It depends how you are confidence to your appearance. Remember, no one will so odd that come & say 光頭佬 to you! :) Take it easy!