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2201^#

發表於 14-3-16 21:22 |只看該作者

回覆 Money18 的帖子

Dear Money18,
Getting HCG=160 with frozen embryo cycle is not bad at all! Frozen cycle is more natural compared to fresh ivf cycle, and in natural conception, at this similar time point, the hcg is often much lower. Do not get overwhelmed by the "low" number (and in fact, it is not low).

If you worry about this brown spotting, try to call your clinic first. If the nurse/doctor thinks this is significant, your dr may ask you to come in; only in very few cases, your dr may give you more medication. Are you on any progesterone (Crinone/endometrin/etc.) right now? In any case, do not go to a general doctor to attend to your brown spotting.

cutecutetown

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Money18

大宅

積分: 1253

2202^#

發表於 14-3-16 22:51 |只看該作者

引用：回覆+Money18+的帖子Dear+Money18,Getting+

原帖由 cutecutetown 於 14-03-16 發表
回覆 Money18 的帖子

Dear Money18,

dear cutecutetown,

好多謝你嘅解釋呀! 個心都定咗好多! 我除咗放胎當日同埋3月7號打咗各一枝安胎針，之後都冇再打針喇! 亦冇塞藥㗎!

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積分: 5171

2203^#

發表於 14-3-23 20:55 |只看該作者

回覆：ivf Q & A

Dear Cutecutetown,

Your advice in this post is very professional and informative. This is my 1st time posting questions here :)

I did ivf this month and just confirm failed. This is my 1st attempt of ivf treat. Here're my background :

1) Age 33, amh 2.8, fsh 6.xx on day 3
2) Fallopian Tube (no blockage on both side)
3) 子宮內膜 - 12mm on day 12
4) Transferred 3 x Day2 embryo (2 Grade A & 1Grade B
5) HCG blood test 14 days after embryo transferred : 2.4
6) Doctor concluded that we are 不明原因不孕

Here're my questions :

1) I've 3 embryos transferred with 2 A Grade & 1 B Grade but failed, do u think it's the implant problem or anything else?

2) Considering the blood test result of HCG 2.4, may I know whether the embryos have implanted or not ?

3) Being the Fsh 6.xx, do I need to take DHEA before next ivf attempt?

4) Is there anyway to increase the succesful rate of ivf treatment ?

Sorry for so many questions and many thanks for your feedback :)

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積分: 5171

2204^#

發表於 14-3-23 21:11 |只看該作者

回覆：ivf Q & A

Dear Cutecutetown,

One more question, from below result, can I assume I've poor response on stimulation process?

Day 10 - Total 7 eggs with size 12mm - 20mm
Day 12 - Total 6 eggs with size 12mm - 17mm
Day 14 - Retrieved 5 eggs
Day 16 - Transferred 3 embryos (2A1B), no frozen embryos

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2205^#

發表於 14-3-25 21:44 |只看該作者

回覆 lovebibibobo 的帖子

Hello lovebibibobo,
1) Probably embryo problem, none of the 3 implanted.

2) No implantation.

3) No need at all to take DHEA, useless in your case.

4) I think you will have a better cycle if you go ahead with a 2nd attempt.

Very often, knowing your age, doctors tend to start your ivf stimulation on a milder dosage. With your 1st ivf cycle, your doctor would have started you on a higher dosage next time and also fine-tune your stimulation protocol.

It is not unusual to see good embryos on day 2. Many of them look good by appearance; and that's how we evaluate them by grading based on morphology. However, as an embryo continues to grow (if it does), we get more clues to their potential. The lab can generally grow embryos to day 5 or day 6, but doctors have a far easier influence on patients to choose which day to do the embryo transfer, especially in the setting in HK. Regardless of which day to transfer, there are also the genetic components that determine an embryo's fate. This genetics does not imply that the parents have genetic diseases; it is very common that when an egg is fertilized and started cell division, there are mitotic errors (errors occur during cell division) so that the chromosomes double but then got unevenly distributed among the cells.

Although ivf is an expensive procedure, it does not guarantee success the first time. While some patients do succeed the first time, many don't. Given your age and good prognosis, it is reasonable to go through a second time and you have a good chance to success.

Good luck,
cutecutetown

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2206^#

發表於 14-3-26 18:08 |只看該作者

回覆：cutecutetown 的帖子

本帖最後由 lovebibibobo 於 14-3-26 19:04 編輯

Hello Cutecutetown,

Many thanks for your advices. Now I feel much more relief and comfortable. At first, I feel myself was very terrible after knowing the ivf result

I kept on questioning myself why it's still failed even though I already had 3 embryos transferred and none of them can survive eventually

If the result is probably due to the embryos problem, does it imply the poor egg / sperm quality? But as I know, my hubby's sperm test result is all passed, so I worry about my egg quality...

I would like to have my 2nd attempt on ivf treatment on coming June, do you think it's reasonable ?

Thanks very much for your advice

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積分: 9500

2207^#

發表於 14-3-28 16:13 |只看該作者

回覆 lovebibibobo 的帖子

Dear lovebibibobo,
Sometimes we can't simply classify it as a sperm problem or an egg problem; it's a little of both, and each factor is inter-related.

There are always limitations to any testing method. For example, when sperm test result is normal, it only tells that there are a good number of sperm, with normal morphology, and most of them swim normally. But the test itself cannot tell us whether this kind of sperm can fertilize an egg under natural condition. That's why it is very difficult to narrow things down to one isolated factor.

It is reasonable to start your 2nd ivf treatment in June. A word of caution, but not an alarm, is that your AMH is 2.8. Do you know the unit of measurement being pmol/L or ng/mL? Based on your 1st time response, the unit is probably pmol/L, meaning your ovarian response to hormonal stimulation is reduced. I don't want you to get over-worried; this AMH implies that you should consider having a baby earlier than later because you will likely have a reduced ovarian response (to hormonal stimulation). With such and as previously discussed, your doctor will start your 2nd ivf on a higher dose with fine-tuning based on progress.

cutecutetown

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2208^#

發表於 14-3-28 16:39 |只看該作者

引用：回覆+lovebibibobo+的帖子Dear+lovebibibob

原帖由 cutecutetown 於 14-03-28 發表
回覆 lovebibibobo 的帖子

Dear lovebibibobo,

Hello Cutecutetown,

The unit of measure is 2.8 ng/ml, is it normal for age 33?

Many Thanks !

點評

cutecutetown Yes, it is "normal", meaning your ovaries will have average response to stimulation. 發表於 14-3-29 13:11

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jlin123

積分: 7632

2209^#

發表於 14-4-1 23:58 |只看該作者

hi cutecutetown,

i just went to a chinese doctor and she said most patients who have unknown problem is due to 免疫性不孕. what's your opinions on that and is there any treatment?

i did some research online and found some background info, especially (4), my doctor said the same thing too not to do it too often. she said i'd better do it on the ovulation day or a day after so that my body won't have enough time to create antibody to kill the sperm or embryo. is this true?

免疫性不孕就相當於是身體裏的能懷孕的因子相互產生了排斥情況，這樣那些能懷孕的因素不能相互結合，就不能生育寶寶，疾病給女性身心帶來極大創傷，所以，了解引起女性免疫性不孕的原因，可起到減少疾病發生的作用。那麼，免疫性不孕的原因有哪些?專家來為大家詳細介紹。　　1、自身免疫：精漿或是女性激素、卵子等溢出生殖道進入了自身周圍的組織，引起自身的免疫反應，在體內產生相應的抗體物質，從而影響到精子的活力，或是對卵泡成熟以及排卵造成影響，引起女性免疫性不孕。
　　2、同種免疫：主要是因女方體內產生抗體，導致精子凝集或是使精子失去活力。有關數據顯示，大概有15%—18%的女性體內存在精子抗力。
　　3、局部免疫：子宮頸粘膜以及子宮內膜中，含有產生免疫球蛋白G和A的淋巴樣細胞，從而導致女性宮頸與生殖道對精子產生局部免疫，引起不孕。
　　4、性生活過頻：因為精子和精液中含有多種蛋白質，若女性朋友性生活過頻，異性蛋白質作為一種抗原物質被女性生殖道吸收後，便很容易激發女性體內產生精子抗體，最終導致免疫性不孕的發生。

thanks!!

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2210^#

發表於 14-4-4 17:37 |只看該作者

回覆 jlin123 的帖子

Dear jlin123,
While you worry about fertility affected by immunological factors, this is still very rare.

And assuming your reference has some merit, it is still only relevant in case of natural conception, i.e. when egg and sperm are following their natural path, traversing the fallopian tube to achieve fertilization. If you do IVF, embryo(s) will be directly transferred into the uterus. Immunological problems affecting implantation are rare, and we do not go about suspecting so when there is no obvious evidence of it.

For natural conception, sexual intercourse should be performed a few days before, or no later than the day of ovulation. This is from the American Society for Reproductive Medicine, a well-established authority in the field. I attach a link below regarding natural fertility and you may take a look:

http://www.reproductivefacts.org/Optimizing_Natural_Fertility_factsheet/

cutecutetown

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jlin123

積分: 7632

2211^#

發表於 14-4-4 23:08 |只看該作者

cutecutetown 發表於 14-4-4 17:37
回覆 jlin123 的帖子

Dear jlin123,

i know. but when you are in a situation where it always fails to implant and doctors cannot identify any problem, it's natural that you would try anything! that's why the only possible explanation that female body reject embryo as foreign object seems to make sense to me.

desperate jlin

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Hihopes

複式洋房

積分: 378

2212^#

發表於 14-6-25 12:43 |只看該作者

Dear Cutecutetown,

I hope to get your expertise on my following questions:

1. Would doing PGS/aCGH cause any harm to a day5 blastocyst? How accurate is this test to identity genetic defects in embryos?

2. Does Elonva injection (7day) achieve identical results in follicle growth as the traditional daily FSH injections?

3. Would the body reject embryo formed using a donor egg?

Thank you very much for your help.

Hihopes

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Coffeesylam

大宅

積分: 1076

2213^#

發表於 14-6-25 13:51 |只看該作者

Dear Cutecutetown

你好！多謝你咁好幫我地d新手JM呀！

我超高0，遲婚，試左半年未可自然懷孕，開始心急睇生育科QM，原本主診醫生商量後決定七月做ivf，但教授醫生檢查時發現兩粒息肉，建議切除及試多幾個月至半年自然懷孕，因為始終未到一年未屬於不孕，結果，上星期已切除，但主診醫生只想比我們試多兩個月，我真係唔知應該聽那一個醫生講，雖然兩位都知道我驗血報告八唔理想AMH0·4，FSH13．6，又想試到年尾，又怕自已越見高0，成功率越低，請問你可以比少許意見我嗎！

謝謝！

C0ffeesy

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積分: 9500

2214^#

發表於 14-6-27 12:16 |只看該作者

回覆 Hihopes 的帖子

Dear Hihopes,
1. In order to do PGS/aCGH, we need to take one cell from a day-3 embryo, or a few cells from a day-5 embryo. There is only a very small chance of damage as in all other procedures.
Depending on what genetic defects you are looking for, accuracy may vary; but bear in mind that there is no single test that is 100% accurate. I assume you are doing aneuploidy screening (and hence Preimplantation Genetic Screening), meaning the procedure will look at the number of chromosomes. It is >95% accurate in most centers.

2. According to studies in Europe, Elonva can achieve similar results as daily injections. It allows the convenience of having one injection that lasts for 7 days. However, Elonva is usually used in women with good/normal ovarian response. I looked back at your old posting and your D3FSH is on the high side. I am not sure if Elonva is appropriate for you.

3. The body would not reject an embryo derived from a donor egg. Some people will consider matching the blood type, hair color, etc. for cultural reasons.

cutecutetown

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2215^#

發表於 14-6-27 13:10 |只看該作者

回覆 Coffeesylam 的帖子

Hello Coffeesylam,
I need to reply in English because the phone app does not work.

How old are you to be 超高0? Your D3FSH and AMH results both indicate a poor ovarian response to hormonal stimulation.

So, will your 主診醫生 let you do IVF? Given your situation (getting married "late" and worried about fertility), you may still try IVF to save time. However, you will need to be prepared that even if you are given an IVF cycle, the success chance is comparatively much lower. Some doctors may not even let you do IVF with the above D3FSH/AMH results; you will need to balance your financial affordability with your desire to seek treatment.

cutecutetown

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Hihopes

複式洋房

積分: 378

2216^#

發表於 14-6-27 13:35 |只看該作者

Dear Cutecutetown,

Wow, I'm so impressed you still remember me from way back. A big thank you for your professional advice and your unwavering support in helping us understanding the many infertility issues.

As for me, after three unsuccessful ivf attempts, I've moved on to waiting for donor eggs. Hopefully it will work....will keep you posted

Many thanks,

Hihopes

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Coffeesylam

大宅

積分: 1076

2217^#

發表於 14-6-27 22:03 |只看該作者

回覆 cutecutetown 的帖子

Dear Curecutetown
Thank you for your replied.

I'm now 40 years old, coming August will be 41 years old....

So that's why it's made me difficult to choose try how long to be natural or fews month later to try as I'VF.....coz doctor let us know whatever natural pregnancy or try IVF chance should be the same

Best regards
Coffeesy

點評

cutecutetown You should still see how long the line for IVF is; perhaps get in-line first, try natural in between 發表於 14-6-28 11:09

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HB-30624700

複式洋房

積分: 158

2218^#

發表於 14-6-28 10:25 |只看該作者

回覆：cutecutetown 的帖子

Hi cutecutetown,
I have been reading your post and reply and find it very informational and comforting for lots of us going through the procedure.

I have a question on pregnancy test. I read some jm here using normal ovulation test kit (LH) for the bingo test. What they do is they test it consecutively for several days before their due, and if they see a stronger signal day by day, it\'s likely a signal for bingo... Just want to understand if that is true and what\'s the reason behind that.

Thanks!!!

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