Hi cutecutetown,
我今次已經第三次ivf放胎失敗了,頭兩次放day3胎,今次是day5,放了一個,有6個雪了(day5),每次都有塞藥同打安胎針,但係都失敗,我想知會唔會系我o既身體對胚胎排斥?定系只可以話因為高齡,卵子質量唔好?我day2既FSH4.7,無驗AMH,我想問仲有什麼方法知道原因呢?多謝。
Dear cutecutetown,
On the day when my eggs were extracted, my husband were asked to give samples for the sperms . My husband has the problem of 弱精症. Unfortunately, in the two samples which were collected within one hour interval, no motile sperms were found. Actually my husband has been consulting an doctor and has done TESA in December. At that time, the lab people said that only occasional motile sperms were seen in the right testis and they have frozen them . But on the day when my eggs were extracted( it is in July), they defrost the sperms and said no motile sperms were found. Then my husband did a MESA ,but again no motile sperms were found. So they did not inject the immotile sperms into my eggs. Finally they have frozen my eggs. I would like to know if it is really useless to inject the immotile sperms into the eggs? Is that the case they cannot fertilise the eggs? And will my eggs die after defrost. I am 37 years old and I wonder if I should give up having babies. Please help.
Hello Micky2014,
Firstly, MESA (MicroEpididymal Sperm Aspiration) and TESA (TEsticular Sperm Aspiration) obtain sperm from 2 different areas along the reproductive tract; so, the maturation state of the sperm extracted might be different.
Do you know if the lab did anything extra to test the viability of the immotile sperm? Immotile sperm could be dead sperm, or they could be immotile but alive.
As for your frozen eggs, there is always a possibility, although very small, that a few or all of them will not survive the freeze-and-thaw process. Assuming they will survive the "defrost", I would suggest to inject them with fresh sperm. This has to be coordinated so that the day of sperm collection/surgical retrieval will match with the day of egg defrost and your natural cycle. Although this sounds complicated, your doctor will coordinate for you; and this is not difficult in your doctor's hands.
When all are well-planned and matched, you can hopefully have an embryo transfer.
Suppose in the worst scenario where there is no sperm from your husband, will you consider using sperm donated from others? What about adoption? There are a number of options available, and you may initiate this discussion with your doctor as well.
其實我一路都好想知驗精洗精過程,主要係人手操作定機器控制?如果人手,咁結果好壞係咪好睇幫我地洗精的胚胎專家手勢同經驗,does human factor actually affects the process?
另一問題係,我做過兩次iui, 我睇返report佢有寫洗精method (swim up 同唔記得另外一個)其實係咪有好多種方法去洗?胚胎專家係咪會跟據情況決定用邊種?因為我老公第一次有千幾萬,第二次用swim up(另一個lab)得返百幾萬條,想知其實有無影響 ,因為嚟緊想做ivf,想了解清楚再選擇,many many thanks
Dear cutecutetown,
Thanks for your reply. We just saw the doctor and the lab people today. The embryologist told us that among the immotile sperms, 7% of them are alive . But after testing the sperms with the chemicals, they can no longer be used for ICSI because the chemicals for testing may bring some unknown harm to the embryos. Actually, I just wonder why the doctor chose to do MESA instead of TESA on the day when my eggs were extracted since occasional motile sperms were found when my husband did TESA in December. Will the result be different if TESA was done that day? We will not consider using sperms donor because both of us still can't accept this plan. We still hope that we can have a baby with our genes. By the way, the embryologist suggested my husband to take 'Preseed plus'. From your expertise, do you think it will work for my husband cause some researches show that this supplement is only effective for those males with sub-optimal sperm quality, but not for males with a high percentage of immotile sperms. And I am wondering if I should seek help from another hospital? Should I consult other doctors? Since it gave me an impression that they could not give us further help. Could you kindly give me some advice? Thank you very much.
原帖由 Micky2014 於 14-07-24 發表
Dear cutecutetown,
Thanks for your reply. We just saw the doctor and the lab people today. The embry ...
Sorry to interupt, just to share my experience to you.
My husband was suggested to take the proxeed plus together with an antioxidant as his sperm test failed in my first iui.
He has taken the supplememts for 3 months. Sperm test showing that mobolity improved just a little bit while the morphology dropped from 1% to less then1%. I am not blaming the supplements for worsensing the morphology but i thought the improvement from supplements only is limited. And for your information, he later consult a 泌尿科doctor and discovered that he has 精索脈曲張。
By the way, my husband said the taste is yucky and he just left the remaining 2 boxes at the corner of the shelf after knowing that it doesnt help.
Hello 森蝶,
"Sperm washing" or preparation is relatively simple and routine. We have the swim-up method and density gradient method. Swim-up is more straight forward; as its name implies, we let the sperm swim from the bottom up. It takes a little more time as compared to density gradient, and usually, this is more suitable with sperm of good motility. On the other hand, density gradient utilizes colloidal reagents to separate out the sperm with good motility from immotile ones. Both methods require some technical staff handling as well as a centrifuge to spin down the preparation. I would say human factor does not affect the process as long as you have a trained person doing it.
When it comes to IUI success rate, we usually talk about the success over 3 cycles of IUI. A woman can get lucky to bingo in her first IUI, but usually we can't see its effectiveness until 3 times have been performed.
As for the sperm report, you need to be very clear about what "number" you are looking at because sometimes we talk about the absolute number of sperm, and sometimes we talk about sperm concentration, which is the number of sperm per volume. Also, the numbers would be different before and after sperm preparation. This probably explained why you saw 千幾萬 and 百幾萬 in the 2 IUI cycles.
Dear Micky2014,
In your case where sperm needs to be retrieved from the epididymis or the testis, I doubt the effectiveness of Preseed Plus, or any other similar products. I can only say that these supplements should do no harm. However, if it tastes horrible (as 森蝶 claimed), why bother taking it?!
Back to your concern, there was probably clinical judgement involved when MESA instead of TESA was done. While testicular aspiration (TESA) might be done, MESA was "easier" especially if no sophisticated surgical set-up is available. It is always tempting to suggest other alternatives when we look retrospectively, so instead of saying what should have been done, you may consult another doctor(s) and see if they can offer further help. Sometimes under a different occasion and a change of hand may benefit.
Dear 森蝶,
A note on sperm morphology. When it's around or below 1%, I would not be too fuss whether it improves or not. For semen analysis, there is sample-to-sample variation, and there is also inter-technician variation. While the absolute values look different, a 0.8% and a 1.1% practically mean the same to me.