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823^#

發表於 11-4-8 08:38 |只看該作者

回覆 Annie888 的帖子

Dear Annie888,

Different factors can affect fertilization rates, whether the fertilization is by conventional IVF or by ICSI. While the eggs and the sperm account for most part of the success of their proper "union", the stimulation protocol, external factors such as cigarette smoking, environmental pollutants, medicines other than those for IVF, and sometimes the lab conditions may have a share of the overall effect.

On average, across the world, conventional IVF gives >60% fertilization per mature oocyte, and ICSI gives >70% per injected oocyte. Be cautious to use these figures because as explained in the above, various factors may cause the rates to be better or worse.

cutecutetown

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824^#

發表於 11-4-8 09:00 |只看該作者

After the above posting, I am sure many jm's will ask,
"it looks like ICSI gives better fertilization rate; why do we continue to use conventional IVF then?"

The reason is because IVF, i.e. by simply putting a fixed amount of sperm in close proximity to the egg(s), the essence of the fertilization mechanism in a natural conception is still retained.

Historically, ICSI was first used to help couples in which the men had very poor sperm. Today we use ICSI to help a much broader range of couples with different subfertility causes. Even though ICSI may boost the fertilization rate, it is still an "invasive" procedure and technically demanding. While IVF labs are staffed with skilled personnel doing ICSI, the risk of compromising the eggs still exists no matter how small this risk is.

After an egg is normally fertilized, its subsequent cell division and developmental potential still very much rely on how good its original materials (sperm & egg) are.

cutecutetown

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piggy_rabbit

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發表於 11-4-8 22:31 |只看該作者

dear cutecutetown,

我是新加入的！我剛剛失敗了第一次的ivf .我有一個疑問，非常感謝你的解答！！我今年已32，我的醫生說我的胚胎質素比較差！他說我的egg 嘅質素一般，但我丈夫的sperm嘅morphology 只有3%！這會是胚胎差的原因嗎？

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miffycat

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826^#

發表於 11-4-8 23:41 |只看該作者

cutecutetown 發表於 11-4-5 23:12
Every now and then this same question comes up in this thread.

Generally, 去大小便 should not aff ...

thousand thanks, cutecutetown!!

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miffycat

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827^#

發表於 11-4-8 23:42 |只看該作者

miffycat 發表於 11-4-8 23:41
thousand thanks, cutecutetown!!

cutecutetown, you are very professional, are you doctor? how come you have so much knowledge on this to share? Anyway, it really helps much!!!

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828^#

發表於 11-4-9 14:23 |只看該作者

回覆 piggy_rabbit 的帖子

hello piggy_rabbit,

Just not everyone would bingo in their 1st ivf. Different women respond to ivf stimulation differently; so, in their 1st time going through ivf, the kind of care we give is based on experience gained from other women. Sometimes this works, sometimes this doesn't work quite well. And then, being 1st-time ivf, the woman herself may also have extra stress because of all the unknowns. Usually if she doesn't suceed, her 2nd-time will be more predictable.

With the embryo quality you mentioned, egg and sperm should be equally important. Morphology is not everything, whether it is the sperm, egg, or the embryo. Often, morphology is not even reliable. I still think genetics plays a bigger part, although we don't have a non-invasive way to tell. The good news is (at least this is how I see it), you are still young and ICSI can help to use your husband's sperm to fertilize your eggs, so, you should still have a good chance. Go for one more ivf and see.

Good luck,
cutecutetown

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829^#

發表於 11-4-9 14:23 |只看該作者

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830^#

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831^#

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parker123

複式洋房

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832^#

發表於 11-4-9 16:10 |只看該作者

Dear cutecutetown,

I am planning to do ET this month, and I have 1xgrade2 embryos with 9 cells, 1xgrade 2- 9 cells and 1xgrade2 8 cells. Normally, Day 3 embryos should have 6-8 cells, but I have 2 two 9 cells, are they normal? I heard that if the embryo grows too fast, it may have chromosome problem, is that true? Thanks.

Parker123

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833^#

發表於 11-4-9 16:31 |只看該作者

回覆 parker123 的帖子

Dear parker123,

I won't be worried with 9-cell; they are at the right speed. Sometimes I get 12-cell on day3, not very common but it is still fine.

As for genetics, we can't really tell based on cell number. In fact, even good-looking embryos can still be genetically abnormal, although with lesser chance when compared to poorer-looking ones.

Can't do much with the genetics unless we can really look inside the embryo. So, the 3 embryos you have seem quite good and if they survive thawing, they should give reasonable chance(s). Good luck,

cutecutetown

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834^#

發表於 11-4-9 16:31 |只看該作者

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835^#

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piggy_rabbit

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837^#

發表於 11-4-9 16:33 |只看該作者

Dear Cutecutetown,

Thanks very much for your professional answer!

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bbbabybb

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838^#

發表於 11-4-9 17:51 |只看該作者

Cutecutetown,

我之前做過兩次iui同一次ivf都失敗，而其中一次iui & ivf完成放精或放胎後大約5-6日都出現發燒情況，會否有機會係我身體覺得胚胎係外來物而產生抗體令我發燒呢？

5w 胎囊 0.97cm
6w 胎囊 1.87cm 胎長 0.48cm (閃閃)
8w2d 胎長 1.9cm
10w2d 胎長 3.7cm

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shirley00171

洋房

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839^#

發表於 11-4-10 15:01 |只看該作者

cutecutetown 發表於 11-4-2 23:41
回覆 shirley00171 的帖子

Hello shirley00171,

cutecutetown,

多謝你的詳細解答.

其實當日醫生幫我放胎時過程頗為順利, 也沒有整痛我, 可能因過度忍尿才得了尿道炎, 吃止痛藥會影響著床的嗎? 還有著床與年齡有重大關係,對嗎? 再過半年我便44歲了, 我與前夫育有一子, 已經23歲, 跟現任丈夫結婚差不多10年, 婚後不久,發現患有子宮內膜異位症, 經腹腔鏡切除異位組織後不久便懷孕, 可惜是宮外孕因而切除了左邊輸卵管。隔了一年，０５年又遇上宮外孕，當時ＱＥ醫生建議做ＩＵＩ，一共做了三次，最終都失敗，醫生便寫轉介信給我到威院排期做ＩＶＦ，在排期過程中，０７年再一次宮外孕（已經第３次）。直到今年２月第一次ＩＶＦ(威院私家隊)亦告失敗, 打針打了13天(Gonal-F 450), 抽蛋5粒, 5粒都有受精, 只有2個胚胎可用, 但質素也接近滿分, 最後放了2個胚胎, 沒有雪胎。我想問, 我應該再做第二次IVF嗎? 如果做之前, 是否需要做一次腹腔鏡, 檢查有沒有子宮內膜異位, 輸卵管積水等問題, 才會增加成功率?

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