Thanks for sharing the photo; it helps a lot in seeing the "shadow". When the egg first grew inside the ovary, it is not yet enclosed by the shell. The shell is deposited around the egg much later when the egg is continuously growing. I sometimes come across eggs with these odd-shaped and irregular shells as well. Usually we will do assisted hatching in these embryos, thinking we may help by creating an easy exit for the embryo to come out and implant. In fact, looking at your report, assisted hatching was done. However, I don't remember seeing any patient bingo from embryos with odd shells.
A little frustrating, isn't it? My guess is that if the shell is irregular, there is probably something wrong during the early growing phase of the egg inside the ovary; either the egg itself is not good or something bad is affecting it. While we may not prevent this from happening again in your next cycle, try to see if the lab agrees to give you embryos with normal round shells (such as the normal-looking one in your photo on the upper right) for ET on day2, day3, or day5. Culture these shadowy embryos to day 5 and see if they will grow to blastocyst stage. If they declare their competence, freeze them for later FET. If they don't grow, there is no point to put them into your uterus.
At least we have a plan for the embryos. Now we need to see if the ring and the pills will give you a better uterine lining. Hope these will work as well. Good luck!
cutecutetown
My 1st IVF failed and I planned to transfer frozen embryo this cycle. Do you think I should try "assist hatching" or anything can increae the chance? Last time, my doctor mentioned that my embryos look good with even and good looking cells proliferation and thin wall. How can I do better this time? In fact, frozen embryos having same successful chance with fresh embryos?
I am sorry about the news. I thought you will be due for a bingo test next week; does miss M return, or is it just brownish spotting?
You may ask your doctor, or the lab, if you will need assisted hatching for the frozen-thawed embryos. Yes, when an embryo is competent, it won't be affected by the freezing and thawing processes and therefore will implant just the same.
Many of us in the field do believe that the endometrium is better in "receiving" the embryos in a FET cycle than the fresh cycle; and my centre's success rates also reflect so. I am not saying that having a fresh ET is no good; in the contrary, just don't think that an FET is inferior to a fresh ET.
I will have the frozen blastocyst transfer tomorrow. Why does the day of transfer after 6 days of progesterone( I use HRT method) nstead of 5 days? Would it matter?Do you have any statistics of success rate of FET using blastocyst? I am aged 40. Last time I bingo on fresh cycle but miscarriaged. Does that signify I haves better chance than average or worse? Just want to be psychologically more prepared. Thank you so much for your kindness
1. In the HRT method, progesterone starts 1 day earlier, similar to the day of egg retrieval (day 0) if it were a fresh cycle. Given your embryo(s) were of day 5, you are on the right track.
2. Generally in FET, blastocyst has a higher success (implantation) rate than cleavage-stage (day2 or day3) embryos.
3. I think I might have mentioned to you in my previous posting. You seem to have a better chance compared to those who are similar of age but have no previous bingo. Your miscarriage was likely due to embryo aneuploidy rather than an insufficient womb. To bingo is only the 1st step, having a normal fetus with its live birth is more important.
So, a few "milestones" for you upcoming --> (a) having at least one good blastocyst for FET --> (b) to bingo --> (c) enter 2nd trimester (>8 weeks) --> (d) live birth.
A fair guess from me: (a) no problem; (b) very good chance if the blastocyst quality is good; (c) since I don't want your blastocyst 小氣, I won't say but pray for you; (d) if (c) is passed, very very good chance.
Sleep well tonight and good luck tomorrow.
cutecutetown
Dear cutecutetown,
I have had my ultrasound today. after 5 days of 375iu gonal f injection, my follicles numbers are not great. only 4! but my blood test level is good - FSH 5.6, LH2.7. There is no sign of ovary malfunction. would it be because my protocol is not suitable. i didn't use "suppression medication" and went to injection directly.
what should i do? should i continue with this cycle? or stop and start another cycle with more follicles?
I don't know if 4 is the total number or the number of faster-growing follicles. Today is only day5 and it's too early to get disappointed; there may be 1-2 more smaller follicles trying to catch up? If so, you will probably have about the same number of eggs as last time; quite reasonable really.
Yes, on one hand your FSH & LH levels indicate that your ovaries are still functional; but some women just do not respond to stimulation drugs as good as expected. I am afraid you may be one of those. Using suppression medication (I assume you refer to nasal spray and the down-regulation method) will not all of a sudden give you 2 dozens of eggs.
Do not give up hope. I get plenty of patients who get few eggs like you and get pregnant alright. The only thing "missing" is that they don't get extra embryos to freeze after transferring their 2 or 3 embryos on day 3. Remember, freezing and storage cost money too; Just be happy with 4, maybe that's your magic number :)
When will your next ultrasound visit be? You may need another 2 scans + blood tests before egg retrieval. I will support you here, and many silent jm's here are also supporting you; "add oil"!!
Yes indeed, 6 blastocysts out of 10 fertilized eggs is a very good result, especially in women >40. You are very brave, and wise, and clever, in choosing to do blast. culture. It is not a difficult logic, but due to a lot of reasons, mainly psychological, many cannot accept it.
I think you have made the right decision and you are very determined not to waste time. I want to give you 五個叻
cutecutetown,
I'm really M ar...
What do you think if I FET on this cycle? Or I need to rest for one cycle? Actually, nothing I need to do, no medication I need to take before FET... I just think I should try on this cycle since I'm old and actually last cycle most factors were pretty good like the embryos' looking, proliferation, uterus wall thickness and 黃體, so I wanna save time...and bingo faster. What do you think?
Thanks for your warm blessings!
點評
cutecutetown
What day is it of your M now? You may ask your doctor about having the FET this month, but most will advise you to take this month off and FET next month.
發表於 11-5-1 10:43
cutecutetown
just wonder what this function is?!
發表於 11-5-1 10:39
Dear miffycat,
I used the 點評 function and gave a short reply which should appear within your same message.
Once again, due to the high dose of hormones you received for egg production, your body is very "confused" and this M may not even ovulate. If FET by natural cycle is the plan, the endometrial environment will not be optimal. Check with your doctor to see what he/she can do to help; but waiting just one month is not a bad idea. Rest and recuperate for a few weeks so that both your body and your mind will come back strong.
cutecutetown
Thank God. I have reached the first milestone. Two blastocysts are put back this morning uneventful. Thank you for your encouragement. Looking forward to updating you more milestone achievement!
點評
cutecutetown
Give you 2 more 叻 !!
發表於 11-5-1 23:25
Gentoomama: your result is very good at your age. Look at me...
Miffycat: start another cycle asap to buy time.
Cutecutetown: thanks very much for advise and support which I didn't even get from my clinic. You're doing this for free. You are way very very kind.
We are just at different stage of luck. Don't feel desperate! I suffered a lot from my last IVF. When I miscarriaged at 8 weeks and lost my twins, I realized what matter is not the quantity but quality which is greatly affected by my age. I can only hope at least one in my six embryos is normal and tough to be a live birth. You will never know what is next waiting for you. Your true one maybe in that a few. All you need is one only! Add oil!
You see, many jm's are here supporting you as well, whether they voice out or not. As said in my last posting, don't give up hope. I can give you little suggestions because you seek answers & comfort here; this is more like a personal platform in which we are one-on-one. Your clinic runs differently. Who knows, maybe you are actually one of my patients?! If so, I really need to talk to your attending doctor......
Just see how this round of ivf reveals, it may not be as bad as you think. I believe you are just very stressed by your supposingly good prognosis. Don't be so harsh on yourself. We will talk again after your next ultrasound visit. Good luck & best wishes,
cutecutetown
I had another u/s sound. I have 4 promising follicles and 2 smaller ones. Anyone proceed to egg retrieval with only 4-6 follicles?
Furthermore, I have asked doctor no need to use full anesthetic to save some money in view of not large number of eggs.
I learnt from a blogfriend that I should have started off with suppression medication first (nose spray, or other medications) to help produce more eggs. Is this correct? Given I haven't had any pregnancy before, with good immune system, had not done IUI before....I'm not responding well to the medication and need some time to boost up the system. Does using suppression medication help boost up my system?
This time, I used suppression medication (cetrotite) only on day 5/6. Is this less idea?
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