I have not posted in this topic for long time. I have a very tough period as I failed my 2nd IVF 2 months ago.
After my first IVF, my doctor suggested me to have long protocol in the second IVF, hoping that it can enhance the quality of my egg. However, it did not work.....
I have 11-12 eggs retrieved in these 2 cycle and about 10 eggs fertilized. However, the quality of the embryo are not satisfactory, which the best one was grade 2-. I did not have any frozen embryo for FET.
As only 32 years old now, my doctor commented that my ovarian function may not be as good as it should be. The quality of egg is similar to those of 40.
I will start my 3rd cycle soon. I would like to ask can the ovarian function reflected by FSH level? (but my doctor told me that my FSH level was normal, however, i don't know the exact level...)Is there any method ,other than FSH, for me to evaluate my ovarian function?
Ovarian function, or test(s) that indicate it, only measures the ability to produce eggs. In your case, as your doc said, FSH is normal, and the number of eggs you produced in both ivf cycles was reasonable. There is unfortunately no test or indicator that can tell us oocyte QUALITY.
A lot of jm's are also troubled by poor oocyte quality. It's hard to pinpoint why or how to improve it if there exists any method to do so. Some may simply use a better-quality stimulation drug, some may be just a random effect depending on "luck" of egg recruitment for that particular cycle, and yet some may be intrinsic problem(s). If you don't mind sharing more with other jm's here, it may be helpful to talk about:
e.g. have you ever got pregnant before,
why would you need ivf,
what stimulation medication did you use,
how many days of stimulation before egg retrieval,
any smoking (second-hand included) or alcohol-drinking habit,
any overweight/underweight issue and diet concerns,
etc. etc.
Hi, I am creamother. Remember me? Just want to share with you that..........I am
I am diabetic, talking metfomin500mgx2per day. I have Ovid. My previous doctor婦科ask me to continue until 12weeks because it can prevent miscarriage in my case. My Ivf doctor cw chan is out of town, the nurse ask me to stop after referring to previous similar case. My 內科doctor asks me to stop but he said some recent report said it can be ok for first 3 months.
How do u think?
點評
cutecutetown
best to consult ivf doctor(s) and follow a more conservative approach
發表於 11-7-18 23:31
cutecutetown
and it may be contraindicated for pregnancies
發表於 11-7-18 23:30
cutecutetown
my limited knowledge is that metformin is "originally" prescribed for diabetic patients
發表於 11-7-18 23:29
Yes, my doc mentioned about intrinsic problem(s). I would like to know what exactly "intrinsic problem" is? I hope my sharing below can help!
-My hubby and me do not smoke or drink alcohol.
-We are not overweight, (may be at worse, near overweight only....mouth:)
-I think we are healthy. I don't have much stress from my work.
-We do not have diet problem and I quitted my favorite coffee already.
-I tried 2 years to conceive naturally. I Failed 3 IUI as well. So I started IVF this year. (the other main reason is that my hubby's sperm morphology is only 3%)
"Intrinsic problem" usually refers to the genetic material of the eggs. As you may know, each woman is born with a fixed number of eggs; these eggs have always been around in the ovaries and will only get "waken" up when they are recruited into menstrual cycles. Therefore, the eggs will also age with the woman, and naturally they will not repair as efficiently as they age (similar to a woman's skin, unfortunately there is no facial treatment for eggs).
Have you done any investigation such as tubal patency or pelvic exam? Did you use HMG or recombinant FSH for stimulation? How many days of FSH injections in your last ivf? Was your ET on day2,3, or 5?
hi there! just wanna update you my recent condition....
ms m visited me again, but unluckiliy, my doctor was on vacation, and so i can't do FET this cycle still...
and i'm somehow bothered by the irregularity of the cycle after IVF...... in the first cycle subsequent to egg retrieval, i ovulated only on day 24-25, and that cycle turned up to be 38 days long....
and then come to the current cycle, i seemed to have ovulated on day 9-10 already, known through using urine test paper (today is day 12).... so it is really short as compared to what i used to have before IVF treatment....
i know it's hard to tell why it become shorter... but can't help feeling weird.... another weird thing is that i had brown fluid coming out on day 9-10 again.... this makes me wonder if my endometrium is too thick again so part of it sheds away gradually after some time....
i guess i'll have ms m visiting again in 2 weeks time... so do u think it's likely that i need a hormonal replacement cycle for FET, given the irregularity observed in these two cycles?
hi there! just wanna update you my recent condition....
Hello JoJoJu,
I think I am so how similar to you after IVF. those days of 排卵蛋白分泌disappeared! Also, I found I lose my sex drive at all..my vaginal become very dry & I have to use KY. it is very different from b4. I used to be quite excited before ovulation & before M comes. And, I used to had PMS, but NOW NO! They are gone! I was shocked coz I heard my doctor said I can have FET after 2 cycles. But, it is obvious that my body is disturbed totally. Is it still a good idea of having FET now? I really doubt.
it's sort of lucky my doctor is on holiday and so there's no chance to do FET this month.
thanks for your reply, and glad to know that there are someone who shared my experiences... coz u know, when you asked doctors or nurses, they give at best amivalent answers.....
my cycles were changed after i did IUI three times.... in the past it's regularlly 28-30 days... but after IUI, it change to alternate long and short cycles, one cycle 25-26 days, then 32-34 days..... but after IVF it's further extended... last cycle 38 days, this cycle probably just 23-24 days.... i think the unsettled feelings come from you dunno what's going on with your body!!
The m cycle subsequent to egg retrieval is almost always shortened or lengthened due to the ivf hormonal injections. Remember in ivf, the hormonal amount is very high that the body won't see under normal physiological condition; so, you really have to wait for your body to return to homeostasis (a state of balance). In many jm's, after the initial long cycle, subsequent cycles (may take ~6 cycles or half a year) become shorter. Nevertheless, these "shorter" cycles are still regular and within the normal time range (24-36 days per cycle, roughly).
Brown fluid.... just a guess, could it be remnants of the little puncture wounds either on the cervix or on the ovaries during egg retrieval?! Since the wounds were physically higher up in the abdomen, the little clotted blood is now finally "washed" down by secretions and body fluid and hence this brownish fluid discharge.
As for sex drive, it is indeed partially driven by hormones. And also ivf is a stressful process, agree? It is stressful to one's emotion, and it is also stressful for the physical well-being. Try to relax and don't set "deadline" for yourselves; when you know how to let go, things will return at the right time.
When both of your doctors return from their vacation, you may ask about natural-cycle FET vs. hormonal replacement. Your doctor will be able to decide which is the best treatment for you. While your doctors are away enjoying themselves, don't be harsh on yourselves either. Take care,
you are welcome. I also wonder if it's only me to feel this distortion. heehee... but I dun want to open a post & say " I dun have sex mood for two months after IVF. Do you feel the same?"....haha.. it will be so funny.
I have HSG and Ultrasound scan of pelvis which were all normal. For the medication for stimulation before, I am not sure.....
I started injection to stimulate ovary on day 3 of period and retrieve egg on day 14-16. ET in day 3.
I met my doc today. He will change the combination of medication he use and may have ET on day 2. I hope he will lead me to the goal this time.
Lastly, thanks for your answer. I would like to know whether genetic material of sperm interfers the division of fertilized egg as well?
Although I don't know which medication you will use, changing the brand may sometimes help.
The paternal contribution (i.e. genetic material from sperm) won't kick in until day3 and beyond. Roughly speaking, when a sperm fertilized an egg, the nutrients and cell machinery are still provided by what the egg originally had. Only when the embryo grows up to around 8-cell, or ~day 3 of development, the maternal source stored (i.e. derived from the egg) would be used up and the embryonic genome will get activated to produce its own nutrients and machinery.
While I don't quite understand the tail description in "其中一個胚胎有兩條尾, 所以把它掉了", 兩條精子同時間成功鑽左入去卵子happens quite often in ivf because we place plenty of sperm around an egg to make fertilization occur in a dish. Eggs have special mechanism to block sperm entry after one sperm has entered; however, when such mechanism is not functioning very well, 2 or more sperm may have gone in, resulting in an embryo with 3 sets of chromosomes. In normal cases, 2 sets of chromosomes are in each embryo, one from the egg (mom contribution) and one from the sperm (dad contribution).
These abnormally fertilized embryos may implant; if so, it may lead to a molar pregnancy (葡萄胎). I suspect it may also lead to early miscarriage as well.
cutecutetown
點評
littletwinkle
thanks for your kind explaination & sorry I did not describe it very well.
發表於 11-7-20 23:46
I will have FET this Saturday, but my Doctor just found out that I got a 1cm 肌瘤 and 0.8mm 息肉 in my 子宮. Will this affect my chance of pregnancy?
My Doctor also said that my E2 level is no good in this cycle, but this can be solved by medication, is this true?
The blood test show that I had ovulate either yesterday or this morning, but my blood test result is a little bit abnormal, which didn't provide a very clear sign of ovulation, and the follicle and egg were not found from ultra sound either. Day15/16 ovulate --> Day18 Transfer two 2Days embryos. My question is if the timing of my FET scheduled on Sat right. My Doctor said it won't make a very big different towards the chance of pregnancy. is it true, or my Doctor is just trying to comfort me?
Don't worry, sometimes it's hard when the doctor explained things to you and you have to re-explain the same to yet another person. I hope I did answer your orginal questions though.
肌瘤 is in the muscular layer of the uterus and it shouldn't affect implantation. Imagine as if your uterus is an orange (a very crude analogy, but I hope it illustrates the point): the muscular layer is like the orange peel, while the endometrial layer where the embryo implants is like the part of the orange meat where the seeds can be found.
I can't really tell if the polyp (息肉) will affect anything; it probably won't or else your doctor would have suggested its removal.
You mentioned E2; are you using natural cycle or hormone-replacement?
The day of ET in your case is just about right. There is an "implantation window", the period of which the uterus is receptive to embryo(s); this window spans over a few days. As long as the embryo growth stage and the uterus is in synchrony and "meet" during this window, implantation can occur. Doctors are very good in timing this event for FET; and we thaw your embryo(s) in the lab at the right time to match the scheduled time frame.
mouth:)
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