Your thoughts on icsi and egg quality have been the widely accepted doctrine for a long time. It is probably still true in most cases. However, is it totally 唔關精子事? It really depends; when sperm is obviously of poor quality, poor fertilization may result. Even when fertilization is ok, subsequent embryo quality may still be suboptimal. As for good-quality sperm (based on semen analyses only), there are recent literature showing that man's age also has an effect on embryo development as well as babies born.
Then, fertilized eggs may or may not divide. Generally, 90% of fertilized eggs will continue to divide. If a fertilized egg does not divide after a day, it just won't develop further. In other words, if it will be transferred, it won't implant nor give bingo. [Back when ivf was first developed, it was routine to transfer fertilized zygotes because the lab couldn't support further embryo growth. Science has improved so much that we can keep blastocysts in culture, i.e. we keep the whole process from egg+sperm to an embryo having potential to implant, this process lasts for 5-6 days outside the womb.]
And yes, usually those websites put "textbook photos" to impress the readers. Having these textbook-looking embryos of course give you a good chance, but we have also had many successes with "average" embryos.
Another yes to每個肧胎專家放得的肧胎都應該只係 2 pronuclei. Each of these pronuclei contains 1 set of chromosomes (染色體), presumably 1 set from mom and 1 set from dad. Although we can see the 2 pronuclei under the microscope, it is beyond our ability to see if the set of 染色體 is normal inside each pronucleus. So, obstetricians still recommend pregnant women to do prenatal screening if they are at risk of carrying abnormal babies, whether they conceive naturally or by ivf.
Life is indeed a miracle; it takes a lot of "correct" combination to make us.
cutecutetown
I have done egg collection on Wednesday (21 Sept 9am) where 3 eggs were collected, & then 2 of them were fertilised normally yesterday. They scheduled me to do day-2 transfer today (Friday 23 Sept 9am).
On the day of egg collection, we agreed to transfer single embryo, but today... one of them is 5-cell & another one is 7-cell already...so they decided to transfer both... & the reason is they're not suitable for freezing....
I just worry why they're growing so fast!? What is your opinion? Thanks~
I often use "只看該作者" function to check because I can only remember your name but not your posts or history, especially you haven't been here for some time.
So, in checking past posts, today is not your 1st-time ivf. It is reasonable to transfer 2 embryos because there was no bingo in your past 2 attempts.
The 5-cell is growing at the right pace, but the 7-cell is a little fast to me. I can't really tell you the reason in your case in particular. Some research studies showed that embryos dividing too slowly or too quickly are probably not very normal. In my lab when I come across these too-fast embryos, I would transfer, if available, other normal-paced embryo(s) and keep the too-fast ones in culture. My reasoning is that if they are competent, i.e. able to grow to a nice blastocyst, I can still freeze at that time. While nothing is absolute, so far I just haven't come across any of these too-fast embryos that can convince me to freeze them; they just stop dividing on day3 or 4 and wouldn't become blastocysts.
I have to emphasize once again that "too fast" means almost double its normal pace; i.e. if on day 2, an embryo should normally be 4-cell; too fast would mean it is about 8-cell or more. For day 3 embryos, ideally they should be 8-cell; too fast would mean about 14-cell or so.
I don't want to stretch too far to speculate if they would implant when they were put back in the uterus. Based on in vitro observation, it seems unlikely they would. If there is no implantation, an embryo as such won't give bingo; so all subsequent event needs not to be over-worried just yet.
My reply above seems a little negative, but this is restricted to your 7-cell only. I would like you to understand that your 5-cell still bears a good chance. It is not too-fast and I have plenty of patients who transferred 5-cell on day2 and bingo alright. Good luck & wish you success this time.
cutecutetown
1. I remember your last bingo was somewhat "borderline" that your hcg index was kind of ok-low to begin with. It could be the embryo itself being aneuploid (some abnormal embryos can implant, but in many cases they miscarry before term or they can be born with some disabilities), or some freeze-thaw damage which was hard to measure by looking at cell number and/or embryo grade.
2. Your last bingo has already proved that it doesn't matter to go 小便 after embryo transfer. Some time ago, we had a jm here (her name is bigears) who had diarrhea almost throughout her entire time from ET to bingo test. She is now into her 2nd or 3rd trimester la.
The womb where your embryo(s) will interact with has a moist surface. You may think of it as a cup of fruit jelly and an embryo is like a piece of small fruit inside. The fruit won't fall out easily just because you move the cup around. Same logic with walking and your normal daily activities; if an embryo will fall out that easily (can't imagine how), the embryo is no good.
There is a slight problem here as I don't know the dosage of your 安胎針, which consists of the same hormone (HCG) as all 驗孕home-test kit or blood test will target at. HCG has a long half-life, i.e. it stays in your blood for many days; in other words, the bigger dose was your 安胎針, the more the chance of a false-positive bingo test.
Although you may indeed bingo, you need to wait a few more days before checking again. You may call your ivf clinic/hospital and tell them the truth to seek some advice. They won't kill you for having 安胎針, but at least they may outline what you can do with the spotting/bleeding.
today is the 9th days after my 2nd fet, but miss m is coming lu（因為同平常一樣有啡同會有便意）.
why miss m 咁早就黎架，仲早過平時。
我上次雖然小產但起碼都有BINGO過，但今次一D蹟象都無仲黎早左添。。。
我好擔心到底係咪我既子寄內膜異位嚴重左，之前令到BB唔再生長，而家仲連著床既能力都無埋。。。定係我既胚胎本身有問題呢？
LITTLEANTANT
點評
糟糟豬
isn't there medication to help support the 黃體? it's just 9th day, will it be not m ah?
發表於 11-10-12 12:54
1. It is almost impossible to have ovulation twice within the same cycle. "紅D有粗線" only indicated you were about to ovulate; most of these ovulation tests were based on your LH hormone. When LH level reaches a high enough level, you get the thick line on the test kit. LH reaches its peak and usually in about 36 hours ovulation will occur. Given you saw 紅D有粗線, in ~2 days from that you will ovulate and then you have to time the embryo development day.
2. When your embryos were frozen on day 3, they may not be necessarily thawed and transferred on the same day. The doctor and the lab will often synchronize the FET day so that your embryo stage matches with your endometrium. Even everything is matched, there is still a chance of no bingo; embryos do not equal babies.
3. The extra culturing time in the lab helps to select out the incompetent embryos. I don't know why doctors like to think and therefore convey the message that extra culture in the lab causes embryo arrest. If an embryo is good (i.e. when it is able to give a baby), it will continue to grow. The extra time in the lab allows us to select and keep only the embryos with good potential. The logic is, do you want many transfer cycles or do you want to get pregnant now? To me, it is important to give you the bingo NOW when there are competent embryos.
In the worst case scenario, suppose you have 10 incompetent embryos only, i.e. none of them can give you a baby. If we culture them to day3, ~6 of them will be "good-looking" 8-cell. If we continue culture to day5, maybe 1 will become a blastocyst. So, suppose you transfer 2 of them on day3, you still have 4 of them left. And probably we will freeze the 4, spending you at least 2 more months in doing FETs before you know it is a complete failure. However, if you culture to day5 and transfer 1 fresh blastocyst, you still end up failing, but you can quickly decide to start another cycle again. Many patients, and even experienced doctors, are still very conservative in thinking that all embryos are good enough to make babies; but in reality, only a few can make it to live births. The success chance varies with different age and different fertility background. When you are still young, you can probably afford to spend the 2 extra months in possibly fruitless cycles; but for those who consider themselves old, it is better to get the bingo as soon as you can, rather than having the false sense of security with whatever number of frozen embryos.
4. If you worry about the complications from multiple pregnancies, you should only transfer 1 embryo and that's when extended culture may help to select. Always be prepared that there may not be an embryo for transfer when you extend culturing time; but if an embryo is no good, why do you want to put it into your womb and go through 2 weeks of anxious waiting for a negative pregnancy test??
I do FET on 6 Oct and it is successful. However, I check ultrasound on 25 Oct and 1 Nov (should be wk 5 and wk 6) and there is only 胎蘘, no heart beat. My Dr said it maybe 小產.
Have you come across any FET or IVF case that like me but can check heart beat until week 7 or week 8?
。
而家已15weeks了. 多謝你之前解答左我好多問題, 你真係好好人, 祝福你日日都開開心心.
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