i'd tried 1 year to be pregnanted natually but failed, then consulted 家計會 doctor for 9 months, within this period, i had done blood test, oviduct checking and my husband also did sperm test, all results are normal as per the doctor said.
my body temp also showed normal 排卵 patern, however, i tried to test 排卵 by using 排卵試紙 for 2 months，there're no positive result occurred, can you tell me why?
i m now doing research for IVF from private hospitals, before that, any other checking or test i should do at this moment?
looking forward for your reply and thanks~
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cutecutetown
I suspect you may not have ovulation every month (ovulate in some but not all the months you tracked
發表於 12-5-8 16:24
Hello choinai,
As commented in your post, I can only suspect you might not have ovulated in every cycle, as shown by 排卵試紙.
The best and easiest way in your case is probably to first consult a fertility specialist, rather than blindly do tests or checking. In some cases, the women may only need ovulation induction alone. The specialist will advise when you should consider ivf after he/she has a full investigation. Such investigation will include only the necessary tests and hopefully can be done at one place and one time.
there would have no ovulation even i have menstruation every month and my body temp showed ovulation patern? how can doctor confirm this? by ultra sound or blood test or whatelse? and if there's any treatment to make me ovulate? hope can have your reply soon!
thanks
點評
cutecutetown
There is medication to induce ovulation.
發表於 12-5-9 12:47
cutecutetown
It's possible; checking body temp is only a very crude method.
發表於 12-5-9 12:47
Hello ccue188,
It is difficult to tell why you only had grade 4 embryos, as age is only one of the factors affecting embryo quality.
Generally speaking, an oocyte should have everything in store to sustain and support development from fertilization up to about 8-cell (or day3 of embryo development); afterwards, the embryonic genome (i.e. a combo of maternal and paternal genes) will take over further development.
And in your case, although sperm could be a factor, it is too early for paternal contribution to start to exert any effect. Since you have just bingo, let's not worry too much about the grading. Afterall, the grading is a morphological assessment at a particular point in time. It provides a reasonable reference, but not the entire picture.
You have achieved the first step of pregnancy. The next milestone is probably to see a fetal sac or fetal heart on ultrasound in about 2-3 weeks time. Meanwhile, keep your mind and body balanced; don't over-worry or indulge in negative thoughts :)
High FSH implies declining ovarian function. With a high FSH, your ovaries won't respond very well to ivf stimulation and too few follicles will develop to make the treatment cost-effective. I suppose you checked your FSH on day3? FSH does vary a little month-to-month, so, check again and see what value you may have.
For AMH, it can be checked any time and remains relatively stable. AMH will be low if you have low ovarian reserve. A value of ~1-3 pmol/L implies a low ovarian response to stimulation and any measurement of <1pmol/L implies negligible response.
IVF has higher success rate than IUI because we usually have more follicles/eggs to work with in ivf. However, IUI is less expensive and you may keep trying almost every month. It is an alternative in your case, but success chance may still be low.
I have tried IUI 5 times and got pregnant 3 times in last 2 years. However, the heartbeat of bbs stopped at around 7W-9W and I have gone through miscarriages 3 times already. Doc cannot explain the reason and we don't know the root cause. Doc suggested us to try IVF.
1) Do you think IVF can solve the problem in my case? I'm not sure if the embryo selection process will help.
2) What's the advantage and disadvantage for an embryo transfer on Day 3 or 5? I heard that a Day 5 transfer will have a better success rate?
3) I saw that many will check FSH before they start the IVF cycle. But my doc said "no need". Will FSH impact any decision for the cycle?
1) IVF probably won't help. Your doctor might think that IVF can create more embryos and by luck you may have at least one good embryo out of the same batch. But this is still try-and-err; no guarantee on solving the miscarriage issue.
2) The better success rate of day5 transfer refers to better bingo chance (prenancy rate), not necessarily live birth rate. The advantage of doing day5 is that it allows better selection in the lab. Let's say we have 6 embryos on day3, all being at the 8-cell stage. How do we know which one have the best potential to implant in the uterus? We really don't know; so, we grow them 2 more days (i.e. to day5) to see which one can reach blastocyst stage. Usually, there may be 2 or 3 able to grow to blastocysts and will be the ones we transfer or freeze. Since these embryos show us their potential, they have a better implantation chance.
And in your case, you got pregnant and carried the fetus up till 7-9 weeks. The issue is not implantation, so day3 vs. day5 is somewhat irrelevant for your situation.
3) FSH is one of the indicators for ovarian function. Your IUI pregnancies show that your ovaries are still functioning ok and that's why your doc said "no need" to check.
Has your doc suggested checking the uterus? By any chance might have checked the abortus? Other medical history that may be connected with your miscarriages?
Doc didn't mention any checking on the uterus. Do you think I need to check sth with the uterus? What needs to be checked? Doc usually mentioned that my uterine lining is quite thin (around 6mm).
I have checked once on the abortus and there was a chromosome issue.
I was with PCOS long long time ago and a wedge resection was done on both ovaries to rectify the issue. Not sure if this is related. I'm afraid that the quality of my eggs are not so good and it causes the miscarriages. I also understand that there's nothing I can do with the egg quality and it will be a try-and-error.
Re day 3 vs 5 transfer - would it be better if i choose day 5 as there is a chance we can get rid of those embryos with "problems"? And that can help to avoid miscarriage to a certain extent?
At this stage, I'm not sure if IVF should be the next step. Or should I try IUI again?
You do not need to check anything on your own. I asked about your uterus status because I don't have any of your background. On the contrary, your doc would have most tests/diagnoses on file with him. Your uterine lining, which is quite thin, provided a possible explanation to your miscarriage. Also, the one time you checked the abortus showed there's a chromosome issue. I will have to leave it to your doctor to find ways to prepare a thicker uterine lining for you if that will be possible.
Your earlier resection of the ovaries should have no effect on conception. If you choose IVF, the marginal benefit for you will be to create numerous embryos so that if the embryo(s) you put back this month fail, you still have a supply of embryos to quickly re-try again. But IVF is a lot more expensive than IUI, and it does not prevent miscarriages.
As for day3 vs day5 transfer, in your case, I believe most of your embryos will become blastocysts anyway, whether they are normal or not, as proven from the fact that your embryo(s) must be able to grow to blastocyst stage before they could implant and yet fail much later. There are plenty of scientific literature telling us that embryo morphology does not correlate to its genetic status; and in among blastocysts, there are still ~40% chance of them being chromosomally abnormal.
Any suggestion for improving the uterine lining? I saw some mentioned taking Vitamin E, does it work? Do you think taking asprin will help too?
When I did IUI, Doc mentioned that the puregon I took would take care of the uterine lining, but I didn't see it worked very well as it was still v thin.
I have a Day 5 FET transfer on 7 May and one embryo is hatched blastocyst is starting to rexpand and one is hatching blastocyst grade 2. I'm very worried as
I tried many cycles of Ivf already. This morning I tried clearblue pregnancy test but said I'm not pregnant. Does that mean I'm really not pregnant? Embedment should be at day 6-8, and Some jm said they have pregnancy result on even day 9. Today it's day 11 and a negative result does reflect true story or I still have to wait until day 14?
Now it is my turn to post a question. I have never compared Clearblue (which is a qualitative test of yes or no, I believe) versus a quantitative hcg test (which measures the actual hcg level in blood). Can any jm tell me, if they had a positive from Clearblue and also did a blood test on the same day, what was the hcg value?
I remembered for my bingo, the same morning I was doing the blood test (that was 12 days after a day 2 transfer) I got a faint line on the clearblue pregnancy test. Later on I recieved my hcg test result and it was 129. I remembered I tested 9 days after transfer and the line was so faint that I couldn't even tell if it's a positive or not.
Happy Mother's Day! And thanks for your reply. I hope everything is fine with you (you make me worry a little when you are still checking this ivf thread)!
It seems that many jm's use Clearblue here to check pregnancy; perhaps it is the most "sensitive" home test available in the market, but I assure you that it is not very sensitive. Another homework jm's can do is to read the leaflet inside Clearblue and see its sensitivity level, or the minimum hcg level it can detect. If an HCG of 139 only gives a faint line, I suspect a level in the range of 50-100 may not be detectable. This is exactly why we don't recommend checking bingo earlier than advised, imagine a pregnant jm "cheats" early on day 9 of embryo development (that's something less than a week after transfer), she may just upset herself by having too much curiosity.
Just like having to raise a child, you will need lots of patience and let your implanted embryo(s) to produce enough hcg for your bingo kit to detect it!!
Add oil for all jm's who are trying, or waiting for a bingo test, or waiting to give birth.
cutecutetown
As mentioned, I have to leave it to your doc to find ways to thicken your endometrial lining. (I can't cross the line as this is medical doctor's territory to decide what to do.) There are certainly ways to do so, but I have to say that it does not work for all jm's.
I am not sure about vitamin E, but at least it won't harm. And I worked in a center when it gave aspirin to some (IVF) patients; and it stopped because there was no beneficial or harmful effect. I did not come across its use in IUI. But you may check with your doc first, because you should not just buy it in Watsons/Mannings and take on your own; you need a dosage from your doc.
Really? I don't know the mechanism how Puregon can help with uterine lining; maybe it's something else your doc mentioned?!
Don't worry, my baby is almost 4 months old. She is such a sweetheart and I enjoyed being a mom very very much. This is my first year celebrating mothers day as a mom.
I agreed very much with what you said about early testing. The line was so faint when I checked 9 days post transfer which made me thought I failed again. I remembered I felt was so down the whole day and I thought I would never be a mom.
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cutecutetown Good, she must be cute!
發表於 12-5-13 23:35
Thank you for your reply. I want to know if a FET hatched blastocyst has a higher chance of bingo? Last cycle I had fresh cycle hatching blastocyst on day 5 but still failed. Very upset last cycle and a bit pressure for this cycle.
點評
cutecutetown
No pressure, just wait a few more days before checking again. See what Whicheng just posted.
發表於 12-5-13 23:33
cutecutetown
No one knows, both your fresh and frozen were blastocysts!
發表於 12-5-13 23:31
Good, she must be cute!
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