I would suggest starting from San Diego downtown, historical district, USS midway, seaworld, San Diego zoo, Legoland, Carlsbad outlet, then Dolphin and whale tour, Disneyland, discovery science center, knotts berry farm. SFO is 6-8 hours from Orange County. Traffic is horrible, so like rose-mag said, plan on starting your drive, like 5-6 am in the morning. Santa Barbara is a good place to stop. We also did the coastal drive this summer, watched the seals and went to cambria, Hearst castle and the lot.
yep, lottoeclee suggestion is very good
actually kids only crazy about Disney and universal studio... all other, better enjoy the beach or stay at down town cafe with sun shine is more relax
life is stressful... no plan is the best plan